Researchers are developing a novel prochlorperazine nasal spray formulation equally a potential novel handling for migraines. This locomote is beingness presented at the 2014 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in addition to Exposition inwards San Diego, Nov. 2-6.
Migraines are manifested past times severe hurting in addition to headache that tin end anywhere from iv to seventy-two hours, accompanied past times nausea, vomiting, in addition to sensitivity to both lite in addition to sound. Of the 100 1000000 people that sense headaches inwards the United States, 37 1000000 of them endure from migraines. According to the Migraine Research Foundation, migraine ranks inwards the locomote past times xx of the world's around disabling medical diseases, amongst somebody inwards the the States going to the emergency room every 10 seconds for treatment.
Venkata Yellepeddi, Ph.D., along amongst his colleagues from Roseman University of Health Sciences, developed a preservative-free device-driven prochlorperazine nasal spray that could seek useful for compounding pharmacists specifically inwards the plain of hurting medicine. "Prochloperazine is a dopamine receptor antagonist that is widely used equally an anti-nausea medication. Comparative clinical studies accept shown that prochloperazine provides improve hurting relief than other anti-migraine drugs such equally sumatriptan, metoclopramide, in addition to ketorolac," said Yellepeddi. "Currently, at that spot are no marketed nasal spray formulations of prochlorperazine available for the handling of migraine. Prochlorperazine is solely available inwards tablet form, which has delayed onrush of action." Yellepeddi in addition to his squad hypothesize that a nasal spray version of prochlorperazine volition non solely locomote effective, but fast acting in addition to accept improve patient compliance overall. Furthermore, this novel production does non accept whatever preservative-related adverse side effects, such equally mucosal irritation which are usually seen amongst vehicles amongst preservatives such equally benzalkonium chloride in addition to potassium sorbate.
Yellepeddi used high functioning liquid chromatography in addition to microbiological assays to assess the stability of prochloperazine nasal spray. These studies demonstrated that the nasal spray was able to rest stable for upwards to 120 days amongst minimal degradation, thus making it an effective handling pick for migraine patients.
The side past times side phase of Yellepeddi's interrogation is to examination the safety, efficacy, in addition to pharmacokinetic studies of the prochlorperazine nasal spray inwards rat beast models.